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According to federal legislation, which of the following medications requires witnessed destruction in a pharmacy?

  1. Ketamine

  2. Duloxetine

  3. Galantamine

  4. Topiramate

The correct answer is: Ketamine

Ketamine is a controlled substance and as per the Controlled Substances Act, it is required to have witnessed destruction in a pharmacy. This is to ensure proper handling and disposal of the medication due to its potential for abuse and diversion. The other options, Duloxetine, Galantamine, and Topiramate, are not controlled substances and therefore do not require witnessed destruction in a pharmacy.