Rock the Pharmacy PEBC Test 2025 – Your Prescription for Success!

Using nonsteroidal anti-inflammatory drugs (NSAIDs) poses a significant risk of gastrointestinal bleeding, which stems from their mechanism of action. NSAIDs work by inhibiting cyclooxygenase (COX) enzymes that are crucial for the production of prostaglandins. Prostaglandins have a protective role in the gastrointestinal (GI) tract; they help maintain the mucosal layer, enhance mucous and bicarbonate secretion, and regulate gastric acid secretion.

When NSAIDs decrease the synthesis of prostaglandins, it compromises the protective lining of the stomach and intestines, making these tissues more susceptible to damage from gastric acid. This can lead to ulceration and bleeding in the gastrointestinal tract. Clinically, this risk is particularly pronounced in certain populations, such as the elderly, individuals with a history of peptic ulcers, or those using high doses or long-term NSAIDs.

In contrast, while increased appetite, skin rash, and increased fatigue can be side effects of certain medications or conditions, they are not specifically associated with the primary adverse effects of NSAIDs to the extent that gastrointestinal bleeding is. The gastrointestinal complications arising from NSAID use are well-documented and are a significant concern when prescribing these medications. Understanding this risk is crucial for